HPK1-IN-34

• CAT Number: I041284
• CAS Number: 2380300-99-0
• Molecular Formula: C25H28N4O2S
• Molecular Weight: 448.58
• Purity: ≥95%
• Synonyms: 4-[3-[[2-amino-5-(2-piperidin-4-yl-1,3-thiazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]-2-methylbut-3-yn-2-ol
• InChI: InChI=1S/C25H28N4O2S/c1-25(2,30)9-6-17-4-3-5-18(12-17)16-31-21-13-20(14-28-23(21)26)22-15-29-24(32-22)19-7-10-27-11-8-19/h3-5,12-15,19,27,30H,7-8,10-11,16H2,1-2H3,(H2,26,28)
• InChIKey: MKDLEIMJLNBFJO-UHFFFAOYSA-N
• SMILES: CC(C)(C#CC1=CC=CC(=C1)COC2=C(N=CC(=C2)C3=CN=C(S3)C4CCNCC4)N)O

HPK1-IN-34（Cat No.:I041284）is a selective inhibitor of the hematopoietic progenitor kinase 1 (HPK1), a critical regulator in immune cell signaling. By targeting HPK1, this compound modulates immune responses, potentially enhancing anti-tumor immunity and regulating inflammation. HPK1-IN-34 is particularly valuable in research on immune-related diseases, including cancer and autoimmune disorders. Its ability to influence T-cell activation and cytokine production makes it a promising candidate for developing therapies that could boost immune system function or suppress harmful immune reactions. Researchers are exploring its potential in both immuno-oncology and autoimmune disease treatments.

Reference

[1]. Xuebin Liao, et al. Hpk1 inhibitors, preparation method and application thereof. Patent WO2019206049A1.