For research use only. Not for therapeutic Use.
HPK1-IN-34 (Compound 143) is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of <100 nM[1]. HPK1-IN-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Catalog Number | I041284 |
| CAS Number | 2380300-99-0 |
| Synonyms | 4-[3-[[2-amino-5-(2-piperidin-4-yl-1,3-thiazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]-2-methylbut-3-yn-2-ol |
| Molecular Formula | C25H28N4O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H28N4O2S/c1-25(2,30)9-6-17-4-3-5-18(12-17)16-31-21-13-20(14-28-23(21)26)22-15-29-24(32-22)19-7-10-27-11-8-19/h3-5,12-15,19,27,30H,7-8,10-11,16H2,1-2H3,(H2,26,28) |
| InChIKey | MKDLEIMJLNBFJO-UHFFFAOYSA-N |
| SMILES | CC(C)(C#CC1=CC=CC(=C1)COC2=C(N=CC(=C2)C3=CN=C(S3)C4CCNCC4)N)O |
| Reference | [1]. Xuebin Liao, et al. Hpk1 inhibitors, preparation method and application thereof. Patent WO2019206049A1. |
