HPOB

• CAT Number: R014607
• CAS Number: 1429651-50-2
• Molecular Formula: C17H18N2O4
• Molecular Weight: 314.30
• Purity: ≥95%
• Synonyms: 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide
• Target: HDAC
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at -20°C
• IUPAC Name: N-hydroxy-4-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]benzamide
• InChI: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)
• InChIKey: RFAZNTABYJYOAR-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO

HPOB (Cat No.:R014607) is a selective inhibitor of histone deacetylase 6 (HDAC6), an enzyme involved in the removal of acetyl groups from lysine residues on histones and non-histone proteins. By inhibiting HDAC6, HPOB promotes the accumulation of acetylated proteins, impacting cellular processes such as protein degradation, cytoskeleton dynamics, and stress response. HPOB is primarily used in research focused on cancer, neurodegenerative diseases, and inflammation, as HDAC6 plays a key role in regulating cancer cell proliferation, protein homeostasis, and immune responses. Its selectivity makes it a valuable tool for studying HDAC6-related pathways.