For research use only. Not for therapeutic Use.
HPPE (compound 236) is a potential Bach1 inhibitor. Bach1 is a transcription factor of the cap’n’collar type alkaline region leucine zipper factor family (CNC-bZip) that regulates mitochondrial metabolism and reduces glucose utilization. HPPE can be used for research in psoriasis, multiple sclerosis, and COPD[1][2].
| Catalog Number | I040793 |
| CAS Number | 1325721-55-8 |
| Synonyms | N-[2-(2-hydroxyethoxy)ethyl]-1-methyl-2-[[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]amino]benzimidazole-5-carboxamide |
| Molecular Formula | C21H20F3N5O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C21H20F3N5O3S/c1-29-16-5-2-12(18(31)25-6-8-32-9-7-30)10-15(16)26-19(29)28-20-27-14-4-3-13(21(22,23)24)11-17(14)33-20/h2-5,10-11,30H,6-9H2,1H3,(H,25,31)(H,26,27,28) |
| InChIKey | BJSHVWKLYLAKTP-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C=C(C=C2)C(=O)NCCOCCO)N=C1NC3=NC4=C(S3)C=C(C=C4)C(F)(F)F |
| Reference | [1]. Attucks, et al. Bach 1 inhibitors in combination with Nrf2 activators and pharmaceutical compositions thereof. World Intellectual Property Organization, WO2016089648 A1 2016-06-09. [2]. Zhang X, et al. Bach1: Function, Regulation, and Involvement in Disease. Oxid Med Cell Longev. 2018 Oct 2;2018:1347969. [3]. Ahuja M, et al. Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2111643118. |
