For research use only. Not for therapeutic Use.
HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells.
| Catalog Number | I047304 |
| CAS Number | 2869954-34-5 |
| Molecular Formula | C31H31ClF3N9O5 |
| Purity | ≥95% |
| Reference | [1] Ferretti S, et al. Nature. 2024 May;629(8011):443-449. |
