HS014 TFA

For research use only. Not for therapeutic Use.

  • CAT Number: I045730
  • Molecular Formula: C73H95F3N20O19S2
  • Molecular Weight: 1677.78
  • Purity: ≥95%
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HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA increases food intake in free-feeding rats[1][2].
Pretreatment with HS014 TFA blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate[2].


Catalog Number I045730
Molecular Formula C73H95F3N20O19S2
Purity ≥95%
Reference

[1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82.
 [Content Brief]

[2]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93.
 [Content Brief]

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