For research use only. Not for therapeutic Use.
HS38（Cat No.:I011927） is a potent and selective inhibitor that targets two kinases: DAPK1 and ZIPK (DAPK3). It demonstrates a high affinity for these kinases, with Kd values of 300nM and 280nM, respectively. Additionally, HS38 acts as an inhibitor of PIM3, with an IC50 of 200nM. This compound has potential applications in the research of smooth muscle-related diseases, suggesting its relevance in investigating and potentially treating such conditions. The specific targeting of DAPK1, ZIPK, and PIM3 makes HS38 a valuable tool in studying the functions of these kinases and their associated pathways.
| Catalog Number | I011927 |
| CAS Number | 1030203-81-6 |
| Synonyms | HS38; HS-38; HS 38;2-((1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)thio)propanamide |
| Molecular Formula | C14H12ClN5O2S |
| Purity | ≥95% |
| Target | DAPK |
| Solubility | Soluble in DMSO |
| Storage | Store at 2-8°C |
| IUPAC Name | 2-[[1-(3-chlorophenyl)-4-oxo-2H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]propanamide |
| InChI | InChI=1S/C14H12ClN5O2S/c1-7(11(16)21)23-14-18-12-10(13(22)19-14)6-17-20(12)9-4-2-3-8(15)5-9/h2-7,17H,1H3,(H2,16,21) |
| InChIKey | BDVPSWBRXLWRCV-UHFFFAOYSA-N |
| SMILES | CC(C(=O)N)SC1=NC(=O)C2=CNN(C2=N1)C3=CC(=CC=C3)Cl |
