HSL-IN-1

• CAT Number: I018776
• CAS Number: 2095156-13-9
• Molecular Formula: C19H13BClF3N2O4
• Molecular Weight: 436.58
• Purity: ≥95%
• Synonyms: [5-chloro-2-[[6-[4-(trifluoromethyl)phenoxy]pyridine-3-carbonyl]amino]phenyl]boronic acid
• InChI: InChI=1S/C19H13BClF3N2O4/c21-13-4-7-16(15(9-13)20(28)29)26-18(27)11-1-8-17(25-10-11)30-14-5-2-12(3-6-14)19(22,23)24/h1-10,28-29H,(H,26,27)
• InChIKey: PDMXSCCBEBCTGX-UHFFFAOYSA-N
• SMILES: B(C1=C(C=CC(=C1)Cl)NC(=O)C2=CN=C(C=C2)OC3=CC=C(C=C3)C(F)(F)F)(O)O

HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability[1].

Reference

[1]. Ogiyama T, et al. Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation. Bioorg Med Chem. 2017 Apr 1;25(7):2234-2243.
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