HSL119

• CAT Number: I047733
• CAS Number: 2231745-56-3
• Molecular Formula: C30H27F3N6O
• Molecular Weight: 544.57
• Purity: ≥95%
• IUPAC Name: but-3-en-2-one;(4Z)-7-fluoro-4-[(4E)-2-fluoro-3-[[(Z)-1-methoxybut-1-enyl]amino]-4-[1-[methyl(6-methyloctan-3-yl)amino]ethylidene]-6-(trifluoromethyl)cyclohexa-2,5-dien-1-ylidene]-2-imino-1-benzothiophene-3-carbonitrile;1-methylpyrrolidine-3-thiol
• InChI: InChI=1S/C33H39F5N4OS.C5H11NS.C4H6O/c1-8-11-26(43-7)41-30-22(19(5)42(6)20(10-3)13-12-18(4)9-2)16-24(33(36,37)38)28(29(30)35)21-14-15-25(34)31-27(21)23(17-39)32(40)44-31;1-6-3-2-5(7)4-6;1-3-4(2)5/h11,14-16,18,20,40-41H,8-10,12-13H2,1-7H3;5,7H,2-4H2,1H3;3H,1H2,2H3/b22-19+,26-11-,28-21-,40-32?
• SMILES: CC/C=C(/NC\1=C(/C(=C\2/C=CC(=C3C2=C(C(=N)S3)C#N)F)/C(=C/C1=C(/C)\N(C)C(CC)CCC(C)CC)C(F)(F)F)F)\OC.CC(=O)C=C.CN1CCC(C1)S

HSL119 is a potent and selective first-generation HUNK inhibitor (IC50 value of ∼1.7μM in JIMT-1 cells). HSL119 has significant efficacy toward treating HER2+ breast cancer, even those that are resistant to HER2 inhibitors. KEYWORDS: HSL119 | Supplier | HUNK inhibitor | HSL 119 | HSL-119 | CAS [2231745-56-3] | HER2 pathway | Rubicon | AMPK | Inhibitor | Enzymes | HER2+ breast cancer | Human epidermal growth factor receptor 2 | Autophagy | Hormonally upregulated neu-associated kinase

Reference

T Dilday et al. Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer. Cell Chem Biol. 2024 May 16;31(5):989-999.