HSP27 inhibitor J2

• CAT Number: I018126
• CAS Number: 2133499-85-9
• Molecular Formula: C13H12O4S
• Molecular Weight: 264.30
• Purity: ≥95%
• Synonyms: 5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)chromen-4-one
• InChI: InChI=1S/C13H12O4S/c1-7-2-10(14)13-11(15)3-8(4-12(13)17-7)16-5-9-6-18-9/h2-4,9,15H,5-6H2,1H3
• InChIKey: VDCWAGBPDCXRDU-UHFFFAOYSA-N
• SMILES: CC1=CC(=O)C2=C(C=C(C=C2O1)OCC3CS3)O

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].
HSP27 inhibitor J2 (10 μM; 12 h) induces significant abnormal HSP27 dimer formation in NCI-H460[1].
HSP27 inhibitor J2 (10 μM; 24 h) increases 17-AAG-induced apoptosis in shCTRL cells[1].

Reference

[1]. Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900.
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[2]. Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.