For research use only. Not for therapeutic Use.
Inhibitor of the collagen-specific chaperone HSP47 with an IC50 value of 3.1 μM. HSP47 inhibitor III suppressed collagen type I expression in human and mouse cells and suppressed the viability and migration of lung fibroblasts.
KEYWORDS: HSP47 inhibitor III | HSP47 inhibitor | CBTC | CAS [287917-38-8] | Serpin | HSP | Inhibitor | Enzymes | Fibrotic disease | Heat shock protein | SERPINH1 | Lung fibrosis
| Catalog Number | I047663 |
| CAS Number | 287917-38-8 |
| Molecular Formula | C8H6ClNO3S2 |
| Purity | ≥95% |
| IUPAC Name | methyl 6-chloro-2-oxo-3H-1,2λ4,3-benzodithiazole-4-carboxylate |
| InChI | InChI=1S/C8H6ClNO3S2/c1-13-8(11)5-2-4(9)3-6-7(5)10-15(12)14-6/h2-3,10H,1H3 |
| SMILES | COC(=O)C1=C2C(=CC(=C1)Cl)SS(=O)N2 |
| Reference | CA Thomson et al. Identification of small molecule chemical inhibitors of the collagen-specific chaperone Hsp47. J Med Chem. 2005 Mar 10;48(5):1680-4. T Miyamura. Small molecule inhibitor of HSP47 prevents pro-fibrotic mechanisms of fibroblasts in vitro. Biochem Biophys Res Commun. 2020 Sep 24;530(3):561-565. |
