HSP90-IN-22

• CAT Number: I041146
• CAS Number: 442898-75-1
• Molecular Formula: C25H30N4O3
• Molecular Weight: 434.53
• Purity: ≥95%
• Synonyms: N-[2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl]-3,4-dimethoxybenzamide
• InChI: InChI=1S/C25H30N4O3/c1-5-28-10-12-29(13-11-28)24-14-17(2)20-16-19(7-8-21(20)27-24)26-25(30)18-6-9-22(31-3)23(15-18)32-4/h6-9,14-16H,5,10-13H2,1-4H3,(H,26,30)
• InChIKey: YGHVMEYBSUHIGF-UHFFFAOYSA-N
• SMILES: CCN1CCN(CC1)C2=NC3=C(C=C(C=C3)NC(=O)C4=CC(=C(C=C4)OC)OC)C(=C2)C

HSP90-IN-22 (Cat No.: I041146) (is a selective small-molecule inhibitor of heat shock protein 90 (HSP90), a molecular chaperone essential for the stability and function of numerous client proteins involved in cancer progression, inflammation, and neurodegeneration. By disrupting HSP90 activity, HSP90-IN-22 promotes the degradation of oncogenic proteins and impairs key signaling pathways. It is a valuable tool for studying proteostasis, stress responses, and the therapeutic targeting of chaperone networks. For research use only in molecular biology and preclinical drug discovery applications.

Reference

[1]. Jiang F, et al. Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors. Eur J Med Chem. 2017 Dec 1;141:1-14.
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