For research use only. Not for therapeutic Use.
HTS07545 is a potent sulfide:quinone oxidoreductase (SQOR) inhibitor with an IC50 of 30 nM. HTS07545 decrease the rate of breakdown of hydrogen sulfide (H2S). HTS07545 can be used for heart failure research[1].
| Catalog Number | I043887 |
| CAS Number | 118666-03-8 |
| Synonyms | ethyl 2-(3-cyano-4,6-diphenylpyridin-2-yl)oxyacetate |
| Molecular Formula | C22H18N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H18N2O3/c1-2-26-21(25)15-27-22-19(14-23)18(16-9-5-3-6-10-16)13-20(24-22)17-11-7-4-8-12-17/h3-13H,2,15H2,1H3 |
| InChIKey | PZNJITRXQKRPFY-UHFFFAOYSA-N |
| SMILES | CCOC(=O)COC1=C(C(=CC(=N1)C2=CC=CC=C2)C3=CC=CC=C3)C#N |
| Reference | [1]. Simon D P Baugh, et al. Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase. Bioorg Med Chem Lett. 2021 Dec 15;54:128443. |
