For research use only. Not for therapeutic Use.
HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1[1].
HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells[1].
HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model[1].
HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration[1].
| Catalog Number | I001751 |
| CAS Number | 1453097-13-6 |
| Synonyms | 4-benzyl-5-methyl-2-(6-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-3-one |
| Molecular Formula | C19H18N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C19H18N4O/c1-12-8-9-16-17(10-12)21-19(20-16)23-18(24)15(13(2)22-23)11-14-6-4-3-5-7-14/h3-10,22H,11H2,1-2H3,(H,20,21) |
| InChIKey | IQOKQFQFGHZHJT-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1)N=C(N2)N3C(=O)C(=C(N3)C)CC4=CC=CC=C4 |
| Reference | [1]. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4. |
