For research use only. Not for therapeutic Use.
Human IgG1 (N297A) kappa, Isotype Control(CAT: I040966) is a genetically engineered monoclonal antibody with an N297A mutation in the Fc region, preventing Fc glycosylation and significantly reducing Fc receptor (FcγR) binding. This modification minimizes antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), making it an ideal negative control for immunological assays. It is used to distinguish non-specific background effects from specific antibody responses in experiments involving immune signaling, therapeutic antibody development, and immune checkpoint studies. Given its role in immune system modulation, this antibody is most relevant to Inflammation & Immunology Research, particularly in evaluating monoclonal antibody therapies and immune interactions.
| Catalog Number | I040966 |
| Purity | ≥95% |
