For research use only. Not for therapeutic Use.
Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].
Humanin (40 nM, rhodamine-conjugated; 30 min) inhibits cell death induced by Bax protein in wild-type HCT116 cells[1].
Humanin (100 μM; 10 min) blocks Bax association with isolated mitochondria, and suppresses cytochrome c release in wild-type HCT116 cells[1].
Humanin reduces half apoptosis induced by 0.2 mM STS[1].
Humanin fails to suppress apoptosis in Bax-deficient HCT116 cells[1].
Humanin (0.375 mg/kg/hr; i.v.) increases peripheral insulin sensitivity in Zucker diabetic fatty (ZDF) rats[2].
| Catalog Number | I041630 |
| CAS Number | 330936-69-1 |
| Molecular Formula | C119H204N34O32S2 |
| Purity | ≥95% |
| Reference | [1]. Guo B, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003 May 22;423(6938):456-61. [2]. Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22;4(7):e6334. |
