HUP30

For research use only. Not for therapeutic Use.

  • CAT Number: I012568
  • CAS Number: 312747-21-0
  • Molecular Formula: C14H15N3O3S
  • Molecular Weight: 305.35
  • Purity: ≥95%
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HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx[1].
HUP30 inhibits Phenylephrine-induced aorta contraction with an IC50 value of 3.9 μM[1].
HUP30 (100 μM) increases cGMP levels in Phenylephrine-stimulated aorta[1].
HUP30 causes an antispasmodic effect on rat aorta rings contracted by 25/30 mM K+, with an IC50 value of 7.5 μM[1].
HUP30 (3-100 μM) inhibits both extracellular Ca2+ influx and Ca2+ mobilization induced by Phenylephrine[1].
HUP30 (10-100 μM) inhibits the current in single tail artery myocytes[1].


Catalog Number I012568
CAS Number 312747-21-0
Synonyms

N-(6-nitro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide

Molecular Formula C14H15N3O3S
Purity ≥95%
InChI InChI=1S/C14H15N3O3S/c18-13(9-4-2-1-3-5-9)16-14-15-11-7-6-10(17(19)20)8-12(11)21-14/h6-9H,1-5H2,(H,15,16,18)
InChIKey VMAKFFKOZSLHDW-UHFFFAOYSA-N
SMILES C1CCC(CC1)C(=O)NC2=NC3=C(S2)C=C(C=C3)[N+](=O)[O-]
Reference

[1]. Fusi F, et al. 2-Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations. Eur J Pharmacol. 2013 Aug 15;714(1-3):178-87.
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