For research use only. Not for therapeutic Use.
HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx[1].
HUP30 inhibits Phenylephrine-induced aorta contraction with an IC50 value of 3.9 μM[1].
HUP30 (100 μM) increases cGMP levels in Phenylephrine-stimulated aorta[1].
HUP30 causes an antispasmodic effect on rat aorta rings contracted by 25/30 mM K+, with an IC50 value of 7.5 μM[1].
HUP30 (3-100 μM) inhibits both extracellular Ca2+ influx and Ca2+ mobilization induced by Phenylephrine[1].
HUP30 (10-100 μM) inhibits the current in single tail artery myocytes[1].
Catalog Number | I012568 |
CAS Number | 312747-21-0 |
Synonyms | N-(6-nitro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide |
Molecular Formula | C14H15N3O3S |
Purity | ≥95% |
InChI | InChI=1S/C14H15N3O3S/c18-13(9-4-2-1-3-5-9)16-14-15-11-7-6-10(17(19)20)8-12(11)21-14/h6-9H,1-5H2,(H,15,16,18) |
InChIKey | VMAKFFKOZSLHDW-UHFFFAOYSA-N |
SMILES | C1CCC(CC1)C(=O)NC2=NC3=C(S2)C=C(C=C3)[N+](=O)[O-] |
Reference | [1]. Fusi F, et al. 2-Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations. Eur J Pharmacol. 2013 Aug 15;714(1-3):178-87. |