For research use only. Not for therapeutic Use.
Hycanthone ethansulfonate（Cat No.:I028951）is a synthetic compound and a derivative of hycanthone, a potent antiparasitic agent originally used in the treatment of schistosomiasis. The ethansulfonate form enhances the compound’s solubility and stability, improving its pharmacological properties. Hycanthone and its derivatives target the parasite’s ability to synthesize DNA, effectively inhibiting its growth and replication. This compound has been studied for its potential in treating various parasitic infections, particularly schistosomiasis, and is of interest in developing more effective treatments for neglected tropical diseases caused by parasitic organisms. Further research is ongoing into its broader therapeutic applications.
| Catalog Number | I028951 |
| CAS Number | 64265-18-5 |
| Synonyms | Hycanthone ethansulfonate |
| Molecular Formula | C22H30N2O5S2 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 1-[2-(diethylamino)ethylamino]-4-(hydroxymethyl)thioxanthen-9-one;ethanesulfonic acid |
| InChI | InChI=1S/C20H24N2O2S.C2H6O3S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20;1-2-6(3,4)5/h5-10,21,23H,3-4,11-13H2,1-2H3;2H2,1H3,(H,3,4,5) |
| InChIKey | MFJJATAOPXFYNI-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCNC1=C2C(=C(C=C1)CO)SC3=CC=CC=C3C2=O.CCS(=O)(=O)O |
| Reference | 1: Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM 3rd, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 2011;6(9):e23679. Epub 2011 Sep 15. PubMed PMID: 21935361; PubMed Central PMCID: PMC3174134. |
