Hydrochlorothiazide

• CAT Number: A000262
• CAS Number: 58-93-5
• Molecular Formula: C7H8ClN3O4S2
• Molecular Weight: 297.7
• Purity: ≥95%
• Synonyms: 58-93-5; Hypothiazide; Esidrix; Oretic; HCTZ
• Target: TGF-beta/Smad
• Storage: -20°C
• InChI: 1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
• InChIKey: JZUFKLXOESDKRF-UHFFFAOYSA-N
• SMILES: C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Hydrochlorothiazide is a thiazide diuretic often used to treat high blood pressure and swelling due to fluid build up. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.

Reference

1: Ashcheulova T, Gerasimchuk N, Rezunenko Y, Demydenko G, Kochubiei O.
PATHOGENETIC ADVANCES OF FOSINOPRIL SODIUM WITH HYDROCHLOROTHIAZIDE IN OBESE
HYPERTENSIVE PATIENTS. Georgian Med News. 2017 Oct;(271):55-61. PubMed PMID:
29099702.

2: Uchiwa H, Kai H, Iwamoto Y, Anegawa T, Kajimoto H, Fukuda K, Imaizumi T,
Fukumoto Y; MAPPY Study Investigators. Losartan/hydrochlorothiazide combination
is safe and effective for morning hypertension in Very-Elderly patients. Clin Exp
Hypertens. 2017 Oct 30:1-7. doi: 10.1080/10641963.2017.1368536. [Epub ahead of
print] PubMed PMID: 29083936.

3: Nwachukwu DC, Eze AA, Nwachukwu NZ, Aneke EI, Agu PU, Azubike NC, Obika LF,
Okoye OI. Monotherapy with amlodipine or hydrochlorothiazide in patients with
mild to moderate hypertension: Comparison of their efficacy and effects on
electrolytes. Malawi Med J. 2017 Jun;29(2):108-112. PubMed PMID: 28955416; PubMed
Central PMCID: PMC5610279.

4: Roy S. Hydrochlorothiazide. AMA J Ethics. 2017 Sep 1;19(9):947-948. doi:
10.1001/journalofethics.2017.19.9.imhl1-1709. PubMed PMID: 28905736.

5: Moinuddin SM, Ruan S, Huang Y, Gao Q, Shi Q, Cai B, Cai T. Facile formation of
co-amorphous atenolol and hydrochlorothiazide mixtures via cryogenic-milling:
Enhanced physical stability, dissolution and pharmacokinetic profile. Int J
Pharm. 2017 Oct 30;532(1):393-400. doi: 10.1016/j.ijpharm.2017.09.020. Epub 2017
Sep 8. PubMed PMID: 28893583.

6: Rezk MR, Fayed AS, Marzouk HM, Abbas SS. A Validated High-Performance
Thin-Layer Chromatographic Method for the Simultaneous Determination of
Zofenopril Calcium and Hydrochlorothiazide in the Presence of the
Hydrochlorothiazide Impurities; Chlorothiazide and Salamide. J AOAC Int. 2017 Sep
11. doi: 10.5740/jaoacint.17-0095. [Epub ahead of print] PubMed PMID: 28893345.

7: Maślanka A, Stolarczyk M, Apola A, Kwiecień A, Hubicka U, Opoka W.
Simultaneous Determination of Acetylsalicylic Acid, Hydrochlorothiazide,
Enalapril, and Atorvastatin in a Polypill-Based Quaternary Mixture by TLC. J AOAC
Int. 2017 Sep 7. doi: 10.5740/jaoacint.17-0107. [Epub ahead of print] PubMed
PMID: 28882196.

8: Gupta VK, Fakhri A, Azad M, Agarwal S. Synthesis of CdSe quantum dots
decorated SnO(2) nanotubes as anode for photo-assisted electrochemical
degradation of hydrochlorothiazide: Kinetic process. J Colloid Interface Sci.
2017 Dec 15;508:575-582. doi: 10.1016/j.jcis.2017.08.083. Epub 2017 Aug 26.
PubMed PMID: 28869914.

9: Mendes C, Buttchevitz A, Kruger JH, Caon T, Benedet PO, Lemos-Senna EMT, Silva
MAS. Chitosan microencapsulation of the dispersed phase of an O/W nanoemulsion to
hydrochlorothiazide delivery. J Microencapsul. 2017 Sep 10:1-12. doi:
10.1080/02652048.2017.1373155. [Epub ahead of print] PubMed PMID: 28847195.

10: Idkaidek N, Agha H, Arafat T. Saliva versus Plasma Bioequivalence of
Valsartan/Hydrochlorothiazide in Humans: Validation of Classes II and IV Drugs of
the Salivary Excretion Classification System. Drug Res (Stuttg). 2017 Aug 28.
doi: 10.1055/s-0043-117775. [Epub ahead of print] PubMed PMID: 28847023.