Hydrochlorothiazide-d2

• CAT Number: R044075
• CAS Number: 1219798-89-6
• Molecular Formula: C7H8ClN3O4S2
• Molecular Weight: 299.74
• Purity: ≥95%
• Synonyms: 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-d2-7-sulfonamide 1,1-Dioxide; Aquarius; Bremil-d2; Cidrex-d2; Dihydrochlorothiazide-d2; Dichlotride-d2; Diurizid-d2; Drenol-d2; Hidrochlortiazid-d2;?Hydrex-d2; Oretic-d2; Pantemon-d2; Thiuretic-d2
• Target: TGF-beta/Smad
• Storage: Room temperature
• IUPAC Name: 6-chloro-3,3-dideuterio-1,1-dioxo-2,4-dihydro-1$l^{6}
• InChI: InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)/i3D2
• InChIKey: JZUFKLXOESDKRF-SMZGMGDZSA-N
• SMILES: [2H]C1(NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl)[2H]

Hydrochlorothiazide-d2 is a deuterated version of hydrochlorothiazide, a widely used diuretic medication for managing hypertension and edema. In this compound, two hydrogen atoms are replaced with deuterium, making it particularly useful in pharmacokinetic and metabolic studies. The deuterium labeling allows for enhanced accuracy in tracking the drug’s absorption, distribution, metabolism, and excretion (ADME) using techniques like mass spectrometry. Hydrochlorothiazide-d2 is essential in pharmaceutical research for studying the drug’s action and optimizing its therapeutic effects while minimizing side effects, providing reliable data for drug development and clinical studies.