For research use only. Not for therapeutic Use.
Hydrocortisone 21-Propionate (Cat No.:C000889) is a synthetic corticosteroid and a derivative of hydrocortisone (cortisol), which is a natural hormone produced by the adrenal glands. As a glucocorticoid, hydrocortisone 21-propionate possesses anti-inflammatory, immunosuppressive, and antipruritic properties. It is commonly used in topical preparations, such as creams, ointments, and lotions, for the treatment of various skin conditions, including eczema, dermatitis, and psoriasis. The propionate ester modification improves its skin penetration and efficacy.
| Catalog Number | C000889 |
| CAS Number | 6677-98-1 |
| Synonyms | (11β)-11,17-Dihydroxy-21-(1-oxopropoxy)pregn-4-ene-3,20-dione; Cortisol 21-Propionate; Hydrocortisone Propionate |
| Molecular Formula | C₂₄H₃₄O₆ |
| Purity | ≥95% |
| Solubility | Ethanol (Slightly), Methanol (Slightly) |
| Appearance | White to Off-White Solid |
| Storage | -20°C, Hygroscopic |
| IUPAC Name | [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate |
| InChI | InChI=1S/C24H34O6/c1-4-20(28)30-13-19(27)24(29)10-8-17-16-6-5-14-11-15(25)7-9-22(14,2)21(16)18(26)12-23(17,24)3/h11,16-18,21,26,29H,4-10,12-13H2,1-3H3/t16-,17-,18-,21+,22-,23-,24-/m0/s1 |
| InChIKey | MRECAIZOMKKXOZ-RPPPWEFESA-N |
| SMILES | CCC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)O |
| Reference | Mason, J. et al.: Br. J. Dermatol., 146, 351 (2002); Sears, H.W. et al.: Clin. Therap., 19, 710 (1997); Otomo, Y.Z. et al.: Nip. Yakur. Zas., 78, 647 (1981); Kitano, Y., et al.: Acta Derm-Venereol., 66, 98 (1986) |
