For research use only. Not for therapeutic Use.
Hydroflumethiazide is a thiazide diuretic with actions. It is also an anti-hypertensive and a diuretic.The physiologic effect of hydroflumethiazide is by means of increased diuresis.
| Catalog Number | R011405 |
| CAS Number | 135-09-1 |
| Synonyms | 3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide;?Bristab; Bristurin; Dihydroflumethiazide; Diucardin; Elodrine; Finuret; Flutizide; Glomerulin; Hidroalogen; Leodrine; Saluron; Vergonil; |
| Molecular Formula | C8H8F3N3O4S2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6} |
| InChI | InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) |
| InChIKey | DMDGGSIALPNSEE-UHFFFAOYSA-N |
| SMILES | C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1 |
| Reference | </br>1:Metabolic effects of propranolol and hydroflumethiazide treatment in Kenyans with mild to moderate essential hypertension. Yonga GO, Ogola EN, Orinda DA.East Afr Med J. 1993 Nov;70(11):696-700. PMID: 8033771 </br>2:Randomised double-blind comparative study of efficacy and safety of hydroflumethiazide and reserpine and chlortalidone and atenolol in the treatment of mild to moderate hypertension in black patients. Maharaj B, van der Byl K.J Hum Hypertens. 1993 Oct;7(5):447-50. PMID: 8263885 </br>3:Comparative study of the efficacy and tolerability of hydroflumethiazide versus propranolol in Africans with mild to moderate hypertension. Ogola EN, Yonga GO.East Afr Med J. 1993 May;70(5):277-9. PMID: 8306902 </br>4:Spectrophotometric determination of hydroflumethiazide. Agrawal YK, Giridhar R, Menon SK.J Pharm Biomed Anal. 1989;7(6):759-63. No abstract available. PMID: 2490778 </br>5:Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Hermansen K, Schmitz O, Mogensen CE.Metabolism. 1985 Aug;34(8):784-9. PMID: 2862565 </br>6:Amorphous spray-dried hydroflumethiazide-polyvinylpyrrolidone systems: physiochemical properties. Corrigan OI, Holohan EM.J Pharm Pharmacol. 1984 Apr;36(4):217-21. PMID: 6144766 </br>7:Interaction of hydroflumethiazide and 2,4-disulfamyl-5-trifluoromethylaniline with cyclic AMP phosphodiesterase and carbonic anhydrase. Brørs O, Braut GS, Braut S, Jacobsen S.Acta Pharmacol Toxicol (Copenh). 1982 Oct;51(4):273-7. PMID: 6295063 </br>8:Pharmacokinetics of hydroflumethiazide during repeated administration in congestive heart failure. Brørs O.Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):177-81. PMID: 7136723 </br>9:Duration of effect of single daily doses of reserpine and hydroflumethiazide evaluated by noninvasive technology in hypertensive patients. Gifford RW Jr, Williams GW, Vidt DG, Bolen K, Acker C.Cleve Clin Q. 1982 Winter;49(4):209-18. No abstract available. PMID: 7168911 </br>10:Effects of hydroflumethiazide in congestive heart failure: renal electrolyte excretion related to urinary thiazide excretion and aldosterone. Brørs O, Enger E, Jacobsen S, Aakvaag A, Foss OP.Acta Pharmacol Toxicol (Copenh). 1981 Nov;49(5):399-406. PMID: 7345881 |
