Hydroxy-α-sanshool

• CAT Number: I018400
• CAS Number: 83883-10-7
• Molecular Formula: C₁₆H₂₅NO₂
• Molecular Weight: 263.38
• Purity: ≥95%
• Target: Neuronal Signaling

Hydroxy-α-sanshool (CAT: I018400) is an alkylamide derived from the pepper that exhibits unique pharmacological properties. It acts as a covalent agonist of the TRPA1 receptor and a non-covalent agonist of the TRPV1 receptor. Its binding and activation of these ion channels result in distinct cellular responses. With an EC50 of 69 µM, Hydroxy-α-sanshool activates TRPA1, contributing to sensory perceptions like pungency and tingling. Moreover, it activates TRPV1 with an EC50 of 1.1 µM, enhancing sensations of heat and pain.

Reference

[1]. Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.