Hydroxy-α-sanshool

For research use only. Not for therapeutic Use.

  • CAT Number: I018400
  • CAS Number: 83883-10-7
  • Molecular Formula: C₁₆H₂₅NO₂
  • Molecular Weight: 263.38
  • Purity: ≥95%
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Hydroxy-α-sanshool (CAT: I018400) is an alkylamide derived from the pepper that exhibits unique pharmacological properties. It acts as a covalent agonist of the TRPA1 receptor and a non-covalent agonist of the TRPV1 receptor. Its binding and activation of these ion channels result in distinct cellular responses. With an EC50 of 69 µM, Hydroxy-α-sanshool activates TRPA1, contributing to sensory perceptions like pungency and tingling. Moreover, it activates TRPV1 with an EC50 of 1.1 µM, enhancing sensations of heat and pain.


Catalog Number I018400
CAS Number 83883-10-7
Molecular Formula C₁₆H₂₅NO₂
Purity ≥95%
Target Neuronal Signaling
Reference

[1]. Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.

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