Hydroxy-PEG1-acid

• CAT Number: I016668
• CAS Number: 89211-34-7
• Molecular Formula: C₅H₁₀O₄
• Molecular Weight: 134.13
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: 3-(2-hydroxyethoxy)propanoic acid
• InChI: InChI=1S/C5H10O4/c6-2-4-9-3-1-5(7)8/h6H,1-4H2,(H,7,8)
• InChIKey: GTIFLSYPOXYYFG-UHFFFAOYSA-N
• SMILES: C(COCCO)C(=O)O

Hydroxy-PEG1-acid（Cat No.:I016668） is a 1 unit polyethylene glycol (PEG) linker that is non-cleavable. It is employed in the synthesis of antibody-drug conjugates (ADCs), which are a class of biotherapeutic molecules. This linker provides a stable attachment between the antibody and the drug payload in ADCs, preventing premature drug release. Hydroxy-PEG1-acid allows for controlled drug delivery, enhancing the therapeutic efficacy of the conjugate. Its non-cleavable nature ensures that the drug remains attached until it reaches the target site, improving the specificity and potency of ADC-based treatments.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.