Hydroxy-PEG1-(CH2)2-Boc

• CAT Number: I016706
• CAS Number: 671802-00-9
• Molecular Formula: C₉H₁₈O₄
• Molecular Weight: 190.24
• Purity: ≥95%
• Target: PROTAC Linkers

Hydroxy-PEG1-(CH2)2-Boc(CAT: I016706) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). PROTACs are innovative molecules that aim to selectively degrade specific target proteins within cells. This linker provides a connection between the target-binding ligand and the ligand that recruits an E3 ubiquitin ligase, leading to the degradation of the target protein through the cellular proteasome machinery. The hydroxy-PEG1-(CH2)2-Boc linker offers a strategy to create PROTAC molecules with potential applications in drug discovery and therapeutic development.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.