For research use only. Not for therapeutic Use.
Hydroxy-PEG2-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016568 |
| CAS Number | 457897-73-3 |
| Synonyms | methyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate |
| Molecular Formula | C8H16O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C8H16O5/c1-11-8(10)2-4-12-6-7-13-5-3-9/h9H,2-7H2,1H3 |
| InChIKey | ZWFWEUBKPURUHJ-UHFFFAOYSA-N |
| SMILES | COC(=O)CCOCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
