For research use only. Not for therapeutic Use.
Hydroxy-PEG3-CH2-Boc is a polyethylene glycol (PEG)-based linker commonly utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This linker consists of a PEG chain with three ethylene glycol units, a hydroxyl group for conjugation, and a Boc (tert-butyloxycarbonyl) protecting group. Hydroxy-PEG3-CH2-Boc provides a flexible and hydrophilic spacer between the target protein-binding ligand and the E3 ubiquitin ligase-recruiting moiety in PROTACs. The linker allows for efficient target engagement and subsequent degradation of the target protein. Its compatibility with PEG-based synthesis strategies makes it valuable for designing and constructing PROTAC molecules with enhanced therapeutic potential.
| Catalog Number | I016587 |
| CAS Number | 518044-31-0 |
| Molecular Formula | C₁₂H₂₄O₆ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| IUPAC Name | tert-butyl 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]acetate |
| InChI | InChI=1S/C12H24O6/c1-12(2,3)18-11(14)10-17-9-8-16-7-6-15-5-4-13/h13H,4-10H2,1-3H3 |
| InChIKey | YZXRUQCLSBHYHG-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)COCCOCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
