For research use only. Not for therapeutic Use.
Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044728 |
| CAS Number | 139115-89-2 |
| Synonyms | 2-[2-(2-hydroxyethoxy)ethoxy]ethyl methanesulfonate |
| Molecular Formula | C7H16O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C7H16O6S/c1-14(9,10)13-7-6-12-5-4-11-3-2-8/h8H,2-7H2,1H3 |
| InChIKey | AVBMDKDBTYOBKO-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)OCCOCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
