Hydroxy-PEG4-C2-methyl ester

• CAT Number: I016566
• CAS Number: 2228857-35-8
• Molecular Formula: C12H24O7
• Molecular Weight: 280.31
• Purity: ≥95%
• Synonyms: methyl 3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C12H24O7/c1-15-12(14)2-4-16-6-8-18-10-11-19-9-7-17-5-3-13/h13H,2-11H2,1H3
• InChIKey: ABLVCDPHCRXTRK-UHFFFAOYSA-N
• SMILES: COC(=O)CCOCCOCCOCCOCCO

Hydroxy-PEG4-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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