Hydroxy-PEG4-CH2COOH

• CAT Number: I016798
• CAS Number: 70678-95-4
• Molecular Formula: C10H20O7
• Molecular Weight: 252.26
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C10H20O7/c11-1-2-14-3-4-15-5-6-16-7-8-17-9-10(12)13/h11H,1-9H2,(H,12,13)
• InChIKey: ZKURGMHPJRDKIR-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCC(=O)O)O

Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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