For research use only. Not for therapeutic Use.
Hydroxy-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I028997 |
| CAS Number | 2079768-50-4 |
| Synonyms | 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| Molecular Formula | C13H26O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H26O8/c14-2-4-18-6-8-20-10-12-21-11-9-19-7-5-17-3-1-13(15)16/h14H,1-12H2,(H,15,16) |
| InChIKey | NQZLSNLBIKBFNP-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCOCCOCCO)C(=O)O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
