Hydroxy-PEG5-Boc

• CAT Number: I016591
• CAS Number: 850090-09-4
• Molecular Formula: C₁₇H₃₄O₈
• Molecular Weight: 366.45
• Purity: ≥95%
• Target: PROTAC Linkers

Hydroxy-PEG5-Boc(CAT: I016591) is a PEG-based linker commonly used in the synthesis of PROTACs (PROteolysis TAgeting Chimeras), a class of molecules designed to induce targeted protein degradation. The hydroxy group in Hydroxy-PEG5-Boc can serve as a point of attachment for various ligands that interact with specific target proteins. The linker provides the necessary flexibility to bridge the target protein and an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent proteasomal degradation of the target protein.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562