Hydroxy-PEG5-C2-methyl ester

• CAT Number: I016565
• CAS Number: 2100306-80-5
• Molecular Formula: C14H28O8
• Molecular Weight: 324.37
• Purity: ≥95%
• Synonyms: methyl 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C14H28O8/c1-17-14(16)2-4-18-6-8-20-10-12-22-13-11-21-9-7-19-5-3-15/h15H,2-13H2,1H3
• InChIKey: ZUAYQXPIWZRYOC-UHFFFAOYSA-N
• SMILES: COC(=O)CCOCCOCCOCCOCCOCCO

Hydroxy-PEG5-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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