Hydroxy-PEG6-CH2-Boc

• CAT Number: I016585
• CAS Number: 297162-47-1
• Molecular Formula: C₁₈H₃₆O₉
• Molecular Weight: 396.47
• Purity: ≥95%
• Target: PROTAC Linkers

Hydroxy-PEG6-CH2-Boc(CAT: I016585) stands as a vital building block in the synthesis of PROTACs (Proteolysis-Targeting Chimeras). This PEG-based linker integrates a hydroxy group and a Boc (tert-butyloxycarbonyl) protecting group, enabling its incorporation into the design of bifunctional molecules. By facilitating the conjugation of target-binding ligands and E3 ligase-recruiting moieties, Hydroxy-PEG6-CH2-Boc plays a pivotal role in constructing PROTACs that harness the cellular degradation machinery to selectively eliminate disease-associated proteins.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562