Hydroxyprocaine

• CAT Number: I029000
• CAS Number: 487-53-6
• Molecular Formula: C13H20N2O3
• Molecular Weight: 252.31
• Purity: 98%
• Synonyms: Hydroxyprocaine; NSC12480; NSC-12480; NSC 12480
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-Diethylaminoethyl 4-aminosalicylate
• InChI: InChI=1S/C13H20N2O3/c1-3-15(4-2)7-8-18-13(17)11-6-5-10(14)9-12(11)16/h5-6,9,16H,3-4,7-8,14H2,1-2H3
• InChIKey: GHSCYMOJHVOGDJ-UHFFFAOYSA-N
• SMILES: OC1=CC(N)=CC=C1C(OCCN(CC)CC)=O

Hydroxyprocaine (Cat.No:I029000) is a local anesthetic and a derivative of procaine. It possesses both analgesic and anesthetic properties, making it useful in medical and dental procedures. Hydroxyprocaine works by inhibiting the transmission of nerve signals, resulting in temporary loss of sensation. It is commonly used as a local anesthetic agent in various clinical settings.

Reference

1: HEKNEBY M. Oxyprocain forte, et nytt lokalanestetikum til bruk i tannlegepraksäs [2-Hydroxyprocaine, a new local anesthetic for dental use]. Nor Tannlaegeforen Tid. 1954 Sep;64(7):283-8. Norwegian. PMID: 13214576.
2: SCHALLER KF, SERIE C. Oxyprocain-Penicillin in der Lepratherapie [Hydroxyprocaine penicillin therapy of leprosy]. Z Haut Geschlechtskr. 1958 Dec 15;25(12):340-6. German. PMID: 13625789.
3: Schmidt AC, Schwarz I. Solid-state characterization of non-stoichiometric hydrates of ester-type local anaesthetics. Part XI. Crystal polymorphism of local anaesthetic drugs. Int J Pharm. 2006 Aug 31;320(1-2):4-13. doi: 10.1016/j.ijpharm.2006.04.017. Epub 2006 May 3. PMID: 16857329.
4: TRAPPMANN R. A new remedy for leprosy, hydroxyprocaine-penicillin. Int J Lepr. 1961 Jan-Mar;29:46-55. PMID: 13777898.
5: HARNISCH H, LAMMERS T. Die klinische Bedeutung der antibakteriellen Eigenschaften von Novocain und Oxyprocain [Clinical significance of antibacterial properties novocaine and hydroxyprocaine]. Arzneimittelforschung. 1953 Nov;3(11):589-91. Undetermined Language. PMID: 13126004.
6: GEDDES IC. Local anaesthetic properties and toxicity of hydroxyprocaine and hydroxyamethocaine. Br J Anaesth. 1956 Feb;28(2):55-66. doi: 10.1093/bja/28.2.55. PMID: 13293283.
7: LIEBERMEISTER K, RUOF H, HUTTNER HJ. Zum Wirkungscharakter von Oxyprocainpenicillin auf Tuberkelbakterien im Brutei [Effect of hydroxyprocaine penicillin on tubercle bacteria in incubated egg]. Z Hyg Infektionskr. 1954;140(5):442-7. German. PMID: 14360235.
8: NAWROCKI G. Antibiotic therapy of tuberculosis with hydroxyprocaine penicillin and paratebin. Dtsch Gesundheitsw. 1954 Apr 29;9(17):532-6. English, German. PMID: 13191063.
9: HIRSCH E, HOLLER W. Die klinische Bedeutung der antibakteriellen Eigenschaften von Novocain und Oxyprocain [Clinical significance of antibacterial properties of novocaine and hydroxyprocaine]. Arzneimittelforschung. 1953 Nov;3(11):592. Undetermined Language. PMID: 13126005.
10: RADENBACH KL, KUNEKE S, LIEBERMEISTER K. Kritische Untersuchungen über Oxyprocainpenicillin und Paratebin [Critical studies on hydroxyprocaine penicillin and paratebin]. Med Monatsschr. 1953 Sep;7(9):555-62. Undetermined Language. PMID: 13119328.