Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)

• CAT Number: I041729
• CAS Number: 71138-97-1
• Molecular Weight: 20-100 (kDa)
• Purity: ≥95%

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg[1].
Hydroxypropylmethyl cellulose acetate succinate (2.5 g/kg; p.o.; single dose) has insignificant acute toxicity in rats[1].
Hydroxypropylmethyl cellulose acetate succinate (0.63, 1.25, 2.5 g/kg; p.o.; once daily for 2 months, 6 days for per weeks) shows insignificant subchronic toxicity in rats[1].
Hydroxypropylmethyl cellulose acetate succinate (1.25 g/kg, 2.5 g/kg; p.o.; once daily for 2 months, 6 days for per weeks) shows insignificant chronic toxicity in rats[1].

Reference

[1]. Hoshi N, et al. Toxicological studies of hydroxypropylmethylcellulose acetate succinate–acute toxicity in rats and rabbits, and subchronic and chronic toxicities in rats. J Toxicol Sci. 1985 Oct;10 Suppl 2:147-85.
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