For research use only. Not for therapeutic Use.
Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC<sub>50</sub> = 10 µg/ml for CYP2D6). It can also inhibit microsomal prostaglandin E<sub>2</sub> synthase-1 (mPGES-1; IC<sub>50</sub> = 1 µM), 5-lipoxygenase activating protein, and sirtuins.
| Catalog Number | R066583 |
| CAS Number | 238074-03-8 |
| Synonyms | Hyp-DCHA;Hyperforin-DCHA |
| Molecular Formula | C47H75NO4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | N-cyclohexylcyclohexanamine;(1R,5R,6R,7S)-2-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-2-ene-4,9-dione |
| InChI | InChI=1S/C35H52O4.C12H23N/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3;11-13H,1-10H2/t27-,33+,34+,35-;/m0./s1 |
| InChIKey | KJVNMVCMFQAPDM-DNSWOBEMSA-N |
| SMILES | CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C.C1CCC(CC1)NC2CCCCC2 |
| Reference | 1.Wentworth, J.M.,Agostini, M.,Love, J., et al. St. John’s wort, a herbal antidepressant, activates the steroid X receptor. Journal of Endocrinology 166, R11-R16 (2000). |
