For research use only. Not for therapeutic Use.
Hypothemycin (Cat.No:I007233) is a natural product derived from certain strains of bacteria. It exhibits potent antifungal activity by inhibiting the enzyme squalene synthase, a key enzyme in fungal sterol biosynthesis. Hypothemycin has been studied for its potential in treating fungal infections and shows promise as a therapeutic agent against fungal diseases.
| Catalog Number | I007233 |
| CAS Number | 76958-67-3 |
| Synonyms | Hypothemycin;(1aR,3S,4S,9S,15bR,Z)-3,4,12-trihydroxy-14-methoxy-9-methyl-3,4,8,9-tetrahydro-1aH-benzo[c]oxireno[2,3-e][1]oxacyclotetradecine-5,11(2H,15bH)-dione |
| Molecular Formula | C19H22O8 |
| Purity | ≥95% |
| Target | MAPK/ERK Pathway |
| Solubility | Soluble in DMSO, not in water |
| Storage | -20°C |
| Reference | </br>1:Hypothemycin inhibits tumor necrosis factor-α production by tristetraprolin-dependent down-regulation of mRNA stability in lipopolysaccharide-stimulated macrophages. Park KH, Yoon YD, Kang MR, Yun J, Oh SJ, Lee CW, Lee MY, Han SB, Kim Y, Kang JS.Int Immunopharmacol. 2015 Dec;29(2):863-8. doi: 10.1016/j.intimp.2015.08.030. Epub 2015 Sep 12. PMID: 26371861 </br>2:Antifungal activity of hypothemycin against Peronophythora litchii in vitro and in vivo. Xu L, Xue J, Wu P, Wang D, Lin L, Jiang Y, Duan X, Wei X.J Agric Food Chem. 2013 Oct 23;61(42):10091-5. doi: 10.1021/jf4030882. Epub 2013 Oct 9. PMID: 24106914 </br>3:Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J.Elife. 2013 Jul 9;2:e00712. doi: 10.7554/eLife.00712. Erratum in: Elife. 2013;e01214. PMID: 23853713 Free PMC Article</br>4:Solid-state circular dichroism and hydrogen bonding, part 2: the case of hypothemycin re-investigated. Pescitelli G.Chirality. 2012 Sep;24(9):718-24. doi: 10.1002/chir.22008. Epub 2012 Jun 6. PMID: 22674780 </br>5:Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, Tang Y.J Am Chem Soc. 2010 Apr 7;132(13):4530-1. doi: 10.1021/ja100060k. PMID: 20222707 Free PMC Article</br>6:The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells. Fukazawa H, Ikeda Y, Fukuyama M, Suzuki T, Hori H, Okuda T, Uehara Y.Biol Pharm Bull. 2010;33(2):168-73. PMID: 20118535 Free Article</br>7:Divergent syntheses of resorcylic acid lactones: L-783277, LL-Z1640-2, and hypothemycin. Dakas PY, Jogireddy R, Valot G, Barluenga S, Winssinger N.Chemistry. 2009 Nov 2;15(43):11490-7. doi: 10.1002/chem.200901373. PMID: 19821460 </br>8:Molecular modeling and crystal structure of ERK2-hypothemycin complexes. Rastelli G, Rosenfeld R, Reid R, Santi DV.J Struct Biol. 2008 Oct;164(1):18-23. doi: 10.1016/j.jsb.2008.05.002. Epub 2008 May 17. PMID: 18571434 </br>9:Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia. Reeves CD, Hu Z, Reid R, Kealey JT.Appl Environ Microbiol. 2008 Aug;74(16):5121-9. doi: 10.1128/AEM.00478-08. Epub 2008 Jun 20. PMID: 18567690 Free PMC Article</br>10:Semisynthesis and cytotoxicity of hypothemycin analogues. Hearn BR, Sundermann K, Cannoy J, Santi DV.ChemMedChem. 2007 Nov;2(11):1598-600. No abstract available. PMID: 17691074 |
