For research use only. Not for therapeutic Use.
HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3[1][2][3].
HyT36 (10 µM; 24 h) decreases the expression of GFP-HaloTag2/Fz4-HaloTag2/GFP-HaloTag7 fusion proteins in HEK293 cells expressing GFP-HaloTag2/Fz4-HaloTag2[1].
HyT36 (10 µM; 2 h or 48 h) reduces the expression of EGFP and increases the binding of Hsp70 and HA-EGFP-HaloTag2 fusion protein in HEK293 Flp-In cells expressing HA-EGFP-HaloTag2[3].
HyT36 (50 nM; 24 h) reduces the level of EGFP-HaloTag2 in HEK293 Flp-In cells expressing HA-EGFP-HaloTag2[3].
HyT36 (1 µM; 4 d) decreases the expression of HA−HaloTag2−HRasG12V in NIH-3T3 cells expressing HA−HaloTag2−HRasG12V[3]
| Catalog Number | I041783 |
| CAS Number | 1323151-45-6 |
| Synonyms | (2R)-4-(1-adamantyl)-N-[2-[2-(6-chlorohexoxy)ethoxy]ethyl]-2-methylbutanamide |
| Molecular Formula | C25H44ClNO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H44ClNO3/c1-20(6-7-25-17-21-14-22(18-25)16-23(15-21)19-25)24(28)27-9-11-30-13-12-29-10-5-3-2-4-8-26/h20-23H,2-19H2,1H3,(H,27,28)/t20-,21?,22?,23?,25?/m1/s1 |
| InChIKey | FRQCQVUXVOJKTG-AXYUOHRYSA-N |
| SMILES | CC(CCC12CC3CC(C1)CC(C3)C2)C(=O)NCCOCCOCCCCCCCl |
| Reference | [1]. Tae HS, et al. Identification of hydrophobic tags for the degradation of stabilized proteins. Chembiochem. 2012 Mar 5;13(4):538-41. [2]. Rubner S, et al. Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells. Org Biomol Chem. 2019 Mar 20;17(12):3113-3117. [3]. Neklesa TK, et al. A bidirectional system for the dynamic small molecule control of intracellular fusion proteins. ACS Chem Biol. 2013 Oct 18;8(10):2293-2300. |
