For research use only. Not for therapeutic Use.
HZ-1157（Cat No.:I007235）is a selective and potent inhibitor of plasma kallikrein, a serine protease involved in the kallikrein-kinin system. By inhibiting plasma kallikrein, HZ-1157 reduces the generation of bradykinin, a mediator of inflammation, pain, and vascular permeability. It is being explored for therapeutic applications in conditions such as hereditary angioedema, diabetic macular edema, and inflammatory diseases. HZ-1157 is also valuable in studying the regulation of the kallikrein-kinin pathway and its role in disease progression, making it a critical tool in inflammation and vascular-related research.
| Catalog Number | I007235 |
| CAS Number | 1009734-33-1 |
| Synonyms | HZ-1157; HZ 1157; HZ1157. Dengue Virus Inhibitor II.;5-(1,1-Dimethylethoxy)- 2,4-quinazolinediamine |
| Molecular Formula | C12H16N4O |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 5-[(2-methylpropan-2-yl)oxy]quinazoline-2,4-diamine |
| InChI | InChI=1S/C12H16N4O/c1-12(2,3)17-8-6-4-5-7-9(8)10(13)16-11(14)15-7/h4-6H,1-3H3,(H4,13,14,15,16) |
| InChIKey | JQHKDYFLRJIBLX-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC1=CC=CC2=C1C(=NC(=N2)N)N |
| Reference | </br>1:Yu Y, Jing JF, Tong XK, He PL, Li YC, Hu YH, Tang W, Zuo JP. Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. doi: 10.1038/aps.2014.55. PubMed PMID: 25066323; PubMed Central PMCID: PMC4125721. |
