I-152

• CAT Number: I041296
• CAS Number: 311343-11-0
• Molecular Formula: C9H16N2O3S2
• Molecular Weight: 264.36
• Purity: ≥95%
• Synonyms: S-[2-[[(2R)-2-acetamido-3-sulfanylpropanoyl]amino]ethyl] ethanethioate
• InChI: InChI=1S/C9H16N2O3S2/c1-6(12)11-8(5-15)9(14)10-3-4-16-7(2)13/h8,15H,3-5H2,1-2H3,(H,10,14)(H,11,12)/t8-/m0/s1
• InChIKey: PCFWUYJHCYCQKP-QMMMGPOBSA-N
• SMILES: CC(=O)NC(CS)C(=O)NCCSC(=O)C

I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties[1].
I-152 (1 mM; 1 h or 2 h) reduces the NRF2 mRNA level in RAW 264.7 cells[1].
I-152 (1 mM; 0-60 min) reduces the level of NRF2 and p53, increases the expression of ATF4 in RAW 264.7 cells[1].
I-152 (0.062, 0.125, 0.25 or 1 mM) increases the level of Gclc mRNA (6 h or 24 h), Chac1 mRNA (6 h or 24 h) and Chop mRNA (6 h) in RAW 264.7 cells[1].
I-152 (0.062, 0.125, 0.25 or 1 mM; 2 h) increases the level of GSH in RAW 264.7 cells[1].
I-152 (1 mM; 1, 2, 6 and 24 h) activates ATF4 mRNA expression in RAW 264.7 cells[1].
I-152 (1 mM; 24 h and 48 h) exhibits cytotoxic and growth inhibitory effects on RAW 264.7 cells[1].

Reference

[1]. Crinelli R, et al. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel). 2021 Jan 26;10(2):175.
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