I-BET 151 dihydrochloride

• CAT Number: I010997
• CAS Number: 1883545-47-8
• Molecular Formula: C23H23Cl2N5O3
• Molecular Weight: 488.37
• Purity: ≥95%
• Synonyms: 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride
• Target: Epigenetic Reader Domain
• Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol and to 100 mM in water
• Storage: Store at -20C
• IUPAC Name: 7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one;dihydrochloride
• InChI: InChI=1S/C23H21N5O3.2ClH/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17;;/h5-11,13H,1-4H3,(H,26,29);2*1H/t13-;;/m1../s1
• InChIKey: UFLKDZBLUNJNJS-FFXKMJQXSA-N
• SMILES: CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)C(C)C5=CC=CC=N5)OC.Cl.Cl

I-BET 151 dihydrochloride(CAT: I010997) is a highly selective inhibitor of bromodomain and extraterminal (BET) proteins, particularly targeting BRD2, BRD3, and BRD4. By disrupting the interaction between BET proteins and acetylated histones, I-BET 151 modulates gene expression, particularly in pathways related to inflammation, cancer, and epigenetic regulation. This compound is a valuable tool in epigenetics research, enabling studies on transcriptional regulation, chromatin remodeling, and the role of BET proteins in disease. I-BET 151 dihydrochloride has shown potential in preclinical models for cancer, cardiovascular diseases, and inflammatory disorders, supporting drug discovery and therapeutic development efforts.