I2906

• CAT Number: I003198
• CAS Number: 331963-29-2
• Molecular Formula: C25H37N3O4
• Molecular Weight: 443.58
• Purity: ≥95%
• Synonyms: 1-ethyl-4-hydroxy-2-oxo-N/’-tridecanoylquinoline-3-carbohydrazide
• Target: Bacterial
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-ethyl-4-hydroxy-2-oxo-N'-tridecanoylquinoline-3-carbohydrazide
• InChI: InChI=1S/C25H37N3O4/c1-3-5-6-7-8-9-10-11-12-13-18-21(29)26-27-24(31)22-23(30)19-16-14-15-17-20(19)28(4-2)25(22)32/h14-17,30H,3-13,18H2,1-2H3,(H,26,29)(H,27,31)
• InChIKey: WIEYSVJHCLJOJT-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCCC(=O)NNC(=O)C1=C(C2=CC=CC=C2N(C1=O)CC)O

I2906（Cat No.:I003198）is a compound that has demonstrated both antimycobacterial and cytotoxic activity against Mycobacterium tuberculosis, the bacterium responsible for tuberculosis (TB). It exhibits promising effectiveness in inhibiting the growth and survival of TB-causing bacteria. Additionally, I2906 displays cytotoxicity, indicating its potential to selectively target and kill infected cells. These findings suggest that I2906 holds promise as a potential candidate for the development of new drugs or treatment strategies against tuberculosis.

Reference

[1]. Lu, Jingning; Yue, Jun; Wu, Jing et al. In vitro and in vivo Activities of a New Lead Compound I2906 against Mycobacterium tuberculosis. Pharmacology (2010), 85(6), 365-371.
Abstract
…Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05).