For research use only. Not for therapeutic Use.
IACS-010759 hydrochloride（Cat No.:I019764）is a potent inhibitor of oxidative phosphorylation, specifically targeting mitochondrial complex I. By disrupting energy production in the mitochondria, IACS-010759 selectively induces apoptosis in cancer cells reliant on oxidative phosphorylation for survival, making it a promising candidate for treating certain cancers, especially those resistant to conventional therapies. Its ability to inhibit complex I also positions it as a tool in research on metabolic vulnerabilities in cancer cells. IACS-010759 is valuable for studying metabolic dependencies in tumors and exploring innovative approaches to cancer therapy.
| Catalog Number | I019764 |
| CAS Number | 1807523-99-4 |
| Molecular Formula | C₂₅H₂₆ClF₃N₆O₄S |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 5-[5-methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole;hydrochloride |
| InChI | InChI=1S/C25H25F3N6O4S.ClH/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28)31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36;/h3-9,14,21H,10-13,15H2,1-2H3;1H |
| InChIKey | LUSCFOVOISLXTM-UHFFFAOYSA-N |
| SMILES | CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F.Cl |
| Reference | [1]. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380 |
