For research use only. Not for therapeutic Use.
IACS-010759（Cat No.:I020093）is a selective inhibitor of mitochondrial complex I, targeting the oxidative phosphorylation pathway critical for ATP production in cells. By blocking complex I, it disrupts energy metabolism, making it particularly effective against cancer cells that rely heavily on oxidative phosphorylation for growth and survival. IACS-010759 induces apoptosis selectively in tumors with high metabolic demands, offering potential as a targeted therapy for specific cancer types, including glioblastoma and AML. This compound is valuable in research on cancer metabolism, exploring vulnerabilities in energy-dependent malignancies for therapeutic intervention.
| Catalog Number | I020093 |
| CAS Number | 1570496-34-2 |
| Molecular Formula | C₂₅H₂₅F₃N₆O₄S |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 5-[5-methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole |
| InChI | InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28)31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14,21H,10-13,15H2,1-2H3 |
| InChIKey | HWJWNWZJUYCGKV-UHFFFAOYSA-N |
| SMILES | CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F |
| Reference | [1]. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380 |
