For research use only. Not for therapeutic Use.
IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM.
| Catalog Number | I045336 |
| CAS Number | 2411321-29-2 |
| Synonyms | 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4-one |
| Molecular Formula | C20H24Cl2N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H24Cl2N4O2/c1-12-19(23)20(11-28-12)6-8-25(9-7-20)16-10-17(27)26(13(2)24-16)15-5-3-4-14(21)18(15)22/h3-5,10,12,19H,6-9,11,23H2,1-2H3/t12-,19+/m0/s1 |
| InChIKey | WYUIJDCKOPRFJO-HXPMCKFVSA-N |
| SMILES | CC1C(C2(CCN(CC2)C3=CC(=O)N(C(=N3)C)C4=C(C(=CC=C4)Cl)Cl)CO1)N |
| Reference | [1]. Czako B, et al. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 Oct 28;64(20):15141-15169. |
