IACS-8803 disodium

• CAT Number: I045480
• CAS Number: 2243079-36-7
• Molecular Formula: C20H23FN10Na2O9P2S2
• Molecular Weight: 738.51
• Purity: ≥95%

IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy[1].
IACS-8803 (10 µg; intra-tumoral injection) shows superior antitumor activity in mice bearing bilateral B16-OVA melanomas[1].

Reference

[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.
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