For research use only. Not for therapeutic Use.
IAXO-101 (Cat.No:I029026) is a small molecule inhibitor that targets the protein kinase B (AKT) signaling pathway. By blocking the activity of AKT, IAXO-101 modulates cell growth, survival, and metabolism. It has shown potential in preclinical studies for the treatment of various types of cancer and is being investigated for its therapeutic applications.
| Catalog Number | I029026 |
| CAS Number | 1202388-64-4 |
| Synonyms | IAXO-101; IAXO 101; IAXO101; |
| Molecular Formula | C42H84INO5 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | N-(((2R,3R,4S,5R,6S)-3-hydroxy-6-methoxy-4,5-bis(tetradecyloxy)tetrahydro-2H-pyran-2-yl)methyl)-N,N-dimethylcyclopentanaminium iodide |
| InChI | InChI=1S/C42H84NO5.HI/c1-6-8-10-12-14-16-18-20-22-24-26-30-34-46-40-39(44)38(36-43(3,4)37-32-28-29-33-37)48-42(45-5)41(40)47-35-31-27-25-23-21-19-17-15-13-11-9-7-2;/h37-42,44H,6-36H2,1-5H3;1H/q+1;/p-1/t38-,39-,40+,41-,42+;/m1./s1 |
| InChIKey | BEFLBKFGGQBVHS-MDMJKWFXSA-M |
| SMILES | C[N+](C)(C[C@@H]1[C@@H](O)[C@H](OCCCCCCCCCCCCCC)[C@@H](OCCCCCCCCCCCCCC)[C@@H](OC)O1)C2CCCC2.[I-] |
| Reference | 1: Hermann JK, Ravikumar M, Shoffstall A, Ereifej ES, Kovach K, Chang J, Soffer A, Wong CT, Srivastava V, Smith P, Protasiewicz G, Jiang J, Selkirk S, Miller RH, Sidik S, Ziats NP, Taylor D, Capadona JR. Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance. J Neural Eng. 2017 Dec 8. doi: 10.1088/1741-2552/aaa03e. [Epub ahead of print] PubMed PMID: 29219114. |
