Ibandronate sodium

• CAT Number: A001092
• CAS Number: 138926-19-9
• Molecular Formula: C9H22NO7P2 • Na [H2O]
• Molecular Weight: 359.2
• Purity: ≥95%
• Synonyms: BM-21.0955
• Target: Apoptosis
• Storage: 3 years -20C powder
• InChIKey: VBDRTGFACFYFCT-UHFFFAOYSA-M

Ibandronate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.Ibandronate (1.25–2 μM) significantly reduces endothelial cell growth, while ibandronate (2 μM) also significantly reduces capillary-like tube formation and increases apoptosis of endothelial cells. Ibandronate (< 100 μM) dose-dependently increases VEGF expression in endothelial cells.Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly reduces the risk of new morphometric vertebral fractures by 62% and 50% (p = 0.0006), respectively, in osteoporotic women after 3 years/’ treatment. Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly and progressively increases BMD of lumbar spine by 6.5% and 5.7%, respectively, in osteoporotic women after 3 years/’ treatment.