Ibandronate Sodium

• CAT Number: I001492
• CAS Number: 138844-81-2
• Molecular Formula: C9H22NNaO7P2
• Molecular Weight: 341.21
• Purity: ≥95%
• Target: Others
• Solubility: H2O: >10 mg/mL
• Storage: 2-8°C
• IUPAC Name: sodium;hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate
• InChI: InChI=1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1
• InChIKey: LXLBEOAZMZAZND-UHFFFAOYSA-M
• SMILES: CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]

Ibandronate Sodium (Cat No.: I001492) is a third-generation bisphosphonate bone resorption inhibitor, which mainly binds with intraosseous hydroxyapatite to inhibit the dissolution and formation of hydroxyapatite, thereby producing an anti-bone resorption effect. effect. In addition, the anti-bone resorption effect of Ibandronate Sodium may also be related to directly changing the formation of bone cells, or directly inhibiting the cytokines mediated by osteoblasts.

Reference

1:Impurity profiling of ibandronate sodium by HPLC-CAD. Wahl O, Holzgrabe U.J Pharm Biomed Anal. 2015 Oct 10;114:254-64. doi: 10.1016/j.jpba.2015.06.002. Epub 2015 Jun 6. PMID: 26092222 2:Effects of ibandronate sodium, a nitrogen-containing bisphosphonate, on intermediate-conductance calcium-activated potassium channels in osteoclast precursor cells (RAW 264.7). Wu SN, Huang YM, Liao YK.J Membr Biol. 2015 Feb;248(1):103-15. doi: 10.1007/s00232-014-9747-8. Epub 2014 Nov 2. PMID: 25362532 3:Stability indicating ion chromatography method for the simultaneous determination of ibandronate sodium drug substance and its impurities. Kumar MN, Kumar KS, Kumar VJ, Prasanna SJ, Sharma HK, Reddy VK.J Pharm Biomed Anal. 2011 Feb 20;54(3):596-601. doi: 10.1016/j.jpba.2010.09.026. Epub 2010 Sep 29. PMID: 20952141 4:New drugs: entecavir, ibandronate sodium, and pegaptanib sodium. Hussar DA.J Am Pharm Assoc (2003). 2005 May-Jun;45(3):412-5. No abstract available. PMID: 15991765